synlayer
cense
How it works

How a case becomes a cited differential

Full architecture and data flow →
01 · Input Your case History, labs, report text
02 · Rules Red flags Specialist-written, run first
03 · Evidence layer Disease packs + library 28 packs Guidelines Literature HPO · LOINC
04 · Language Model drafts Replaceable; may cite only the evidence layer
05 · Verify Citation check Unsourced sentences removed
06 · Output Cited differential Top 5, with sources
When the case is too thin to rank, Cense asks up to three questions before it ranks anything.
Physician reports and expert review feed back into the evaluation set.

What a case review shows

01 · Input

Start from what is already in the chart

Type or paste the history and reports, or photograph a lab sheet. Direct identifiers are blocked before anything is uploaded.

A photographed laboratory report, illustrative
New case 1 photo · OCR
Text only. Remove names and identifiers before you paste.
1
ConsiderMyasthenia gravis
Guideline-recommended
SupportsFluctuating ptosis and diplopia, worse by evening.
SupportsProximal weakness that recovers with rest.
MissingAcetylcholine receptor antibodies still pending.
2
ConsiderMultiple sclerosis
Limited evidence
SupportsDiplopia can be an early presenting sign.
Argues againstWeakness that recovers with rest points away from a central lesion.
02 · Differential and why

Ranked candidates with a computed confidence

Up to five candidates from the covered diseases. Confidence is calculated from evidence coverage and rule hits rather than taken from the model.

03 · Missing and next tests

What is missing, and which test to order next

For each candidate, the tests that would rule it in or out, ordered by how much each one would change the ranking.

Acetylcholine receptor antibodies
Pending on the lab sheet; would raise or lower myasthenia gravis.
Repetitive nerve stimulation
If serology is negative.
Thyroid function
Already in the case.
Ordered
Neuromuscular centerExample university center28 mi · Accepts referrals · Remote consult
Rare-disease centerExample regional center64 mi · Accepts referrals
04 · Refer

Where to refer

Rare-disease centers in the physician's region, with their referral criteria and, where offered, a remote-consult route.

05 · Out of scope

When the case does not fit

If the case does not match any covered disease, Cense reports that and lists what would help.

Not enough to go on yet. Here’s what would help.

  • Add the timeline of symptoms, with onset and pattern.
  • Paste recent labs, with units and dates.
  • Attach imaging or pathology reports as text.

How the evidence is reviewed and tested

Evidence and safety →